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Operation ENDGAME Strikes Again: Global Law Enforcement Breaks Ransomware Kill Chain at the Source

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In a sweeping international crackdown, law enforcement agencies dismantled the infrastructure behind multiple ransomware operations from 19 to 22 May 2025. Dubbed Operation ENDGAME, this unprecedented action disabled initial access malware services, neutralized 650 domains, and seized over €21.2 million in cryptocurrency crippling the ransomware ecosystem at its root.

A coalition of law enforcement agencies executed simultaneous takedowns across Canada, France, Germany, Denmark, the Netherlands, the United Kingdom, and the United States, supported by Europol and Eurojust. This wave of action targeted the infrastructure enabling some of the most dangerous malware strains used for ransomware deployment.

According to Europol’s statement released on 20 May 2025, authorities:

  • Took down over 300 servers
  • Neutralized 650 domains
  • Seized over €3.5 million in crypto, adding to the previously recovered €17.7 million
  • Issued 20 international arrest warrants
  • Targeted and neutralized seven malware variants (see TTPs section)

This joint strike is the second major phase of the Operation ENDGAME, which first launched in May 2024 against global botnets. In 2025, the focus sharpened on initial access malware, a critical link in the ransomware kill chain.

Disrupting the Malware-as-a-Service Market

The malware variants taken down include:

  • Qakbot
  • Trickbot
  • DanaBot
  • HijackLoader
  • Warmcookie
  • Bumblebee
  • Lactrodectus

These are instrumental in providing access for ransomware operators and are typically distributed via phishing, drive-by downloads, or malicious ads. Their removal represents a significant blow to the cybercrime-as-a-service economy.

“By disrupting the services criminals rely on to deploy ransomware, we are breaking the kill chain at its source.”
Catherine De Bolle, Europol Executive Director

The MEA Perspective: Vigilance in a Shifting Threat Landscape

Why This Matters for Middle East and Africa

The MEA region has become an increasingly lucrative target for cybercrime due to rapid digital transformation, expanding cloud adoption, and emerging fintech ecosystems.

While Operation ENDGAME was largely centered in Europe and North America, its implications ripple across MEA:

  • Several domains and servers disrupted were hosted in African cloud regions.
  • Agencies like CERT-MU (Mauritius) and NCA-ZA (South Africa) reported increased attempted connections from takedown-linked IPs before the operation.
  • With the rise of data protection laws like Nigeria’s NDPR, the crackdown provides a blueprint for regional policymakers to regulate initial access brokers.

“This operation sets a global precedent. Regional CSIRTs must now proactively update their IOCs and revamp their awareness campaigns.”
Ayodele Badmus, CTO at Lagos-based CyberSecure360

Global Comparison: Law Enforcement Learns to Fight Smart

Operation ENDGAME shows growing maturity in international cybercrime coordination:

OperationFocusResult
Operation Endgame 2024Botnets (Qakbot, Emotet)Takedown of command-and-control infrastructure
Endgame 2025Initial Access MalwareKill chain disrupted, 20 suspects wanted
Operation Cronos (2023)Lockbit gang disruptionArrests, crypto seizure, partial restoration of services

Where 2024 was about cleanup, 2025 is about prevention—striking at ransomware’s entry points before payloads are deployed.

Tactics, Techniques, and Procedures (TTPs)

MITRE ATT&CK Mapping & IOCs (Boxed section)

  • Initial Access: Spear phishing (T1566.001), malicious ads (T1189)
  • Execution: DLL side-loading (T1574.002)
  • Persistence: Scheduled tasks (T1053.005), registry run keys (T1547.001)
  • Defense Evasion: Obfuscated files/scripts (T1027), signed binary proxy execution (T1218.011)
  • Command and Control: Encrypted C2 via HTTPS (T1071.001)
  • IOC Samples:
    • Domains: bumpsecure[.]xyz, danatrace[.]top
    • IPs: 185.202.2.111, 45.77.99.64
    • File hashes (DanaBot variant): e5f4cd9f..., c9a25de2...

Actionable Takeaways for CISOs and Security Leaders

  1. Update blocklists with domains and IPs linked to Operation ENDGAME.
  2. Audit endpoints for presence of any initial access malware such as Qakbot or HijackLoader.
  3. Use threat intelligence feeds from cybercory.com to monitor evolving IOCs.
  4. Increase user awareness training to identify phishing and malvertising campaigns.
  5. Patch early, patch often—many malware variants exploit known CVEs.
  6. Deploy EDR/XDR solutions to detect lateral movement and anomalous persistence mechanisms.
  7. Monitor for exfiltration via encrypted C2 channels.
  8. Engage with local CERTs for updated guidance and mitigation strategies.
  9. Review third-party access and enforce MFA across all externally facing portals.
  10. Include initial access scenarios in red teaming and tabletop exercises.

Conclusion: Disruption Is Not Defeat—But It Buys Time

Operation ENDGAME proves that dismantling the infrastructure of cybercrime is possible when global cooperation is prioritized. But cybercriminals are agile they will retool, rebuild, and return.

For defenders, this is a critical window to harden systems, update security controls, and disrupt future attack chains before they start. As the upcoming IOCTA 2025 report highlights, the war against ransomware begins at its point of entry. Let’s act accordingly.

Sources

Ouaissou DEMBELE
Ouaissou DEMBELEhttp://cybercory.com
Ouaissou DEMBELE is a seasoned cybersecurity expert with over 12 years of experience, specializing in purple teaming, governance, risk management, and compliance (GRC). He currently serves as Co-founder & Group CEO of Sainttly Group, a UAE-based conglomerate comprising Saintynet Cybersecurity, Cybercory.com, and CISO Paradise. At Saintynet, where he also acts as General Manager, Ouaissou leads the company’s cybersecurity vision—developing long-term strategies, ensuring regulatory compliance, and guiding clients in identifying and mitigating evolving threats. As CEO, his mission is to empower organizations with resilient, future-ready cybersecurity frameworks while driving innovation, trust, and strategic value across Sainttly Group’s divisions. Before founding Saintynet, Ouaissou held various consulting roles across the MEA region, collaborating with global organizations on security architecture, operations, and compliance programs. He is also an experienced speaker and trainer, frequently sharing his insights at industry conferences and professional events. Ouaissou holds and teaches multiple certifications, including CCNP Security, CEH, CISSP, CISM, CCSP, Security+, ITILv4, PMP, and ISO 27001, in addition to a Master’s Diploma in Network Security (2013). Through his deep expertise and leadership, Ouaissou plays a pivotal role at Cybercory.com as Editor-in-Chief, and remains a trusted advisor to organizations seeking to elevate their cybersecurity posture and resilience in an increasingly complex threat landscape.

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